|
KMID : 0928320090090020148
|
|
Korean Journal of Health Promotion and Disease Prevention
2009 Volume.9 No. 2 p.148 ~ p.153
|
|
|
Association of Obesity Linked Factors, and Inflammatory Factors with Leptin Hormone in Female College Students
|
|
Choi Hea-Gin
Cho Jung-Ho
Lee Jong-Do
Shin Mal-Ryun
Lee Ji-Hyun
Choi Bo-In
Kim Hee-Jung
Kim Sun-Min
Jung Jae-Hyun
Jung Sang-Sun
Yang Myoung-Joo
|
|
|
Abstract
|
|
|
Background: Leptin is a protein hormone produced primarily by fat cells and plays a key role in regulating energy intake and expenditure including appetite and metabolism. But whether leptin is associated with obesity-linked factors and inflammatory factors across gender is not clear. We investigated the relationships between leptin and obesity-linked factors (weight, percent body fat,
waist-hip-ratio, body mass index, blood pressure, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride) and inflammatory factors (interleukin-6, C-reactive protein, tumor necrosis factor-α, and white blood cell) in 31 female college students.
Methods: We measured total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), interleukin--6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), white blood cell (WBC), and leptin hormone level using an enzymatic method. Percent body fat, fat mass, weight, height, waist-hip ratio (WHR), and body mass index (BMI) were analyzed using bioelectrical impedance (Biospace Co.), and blood pressure was measured by auto blood pressure machine (MD 730, Korea). Pearson product-moment correlation was used to investigate correlations between leptin and obesity-linked factors and inflammatory factors. Multiple linear regression was used to examine the associations between leptin and obesity-linked factors and inflammatory factors.
Results: Leptin was significantly associated with weight (r=0.59, p=0.00), percent body fat (r=0.80, p=0.00), WHR (r=0.81, p=0.00), BMI (r=0.67, p=0.00), LDL-C (r=0.43, p=0.02), and CRP (r=0.40, p=0.03). In multiple linear regression analysis, percent body fat (t=6.39) and HDL-C (t=2.18) were shown to be significant predictors of the body’s level of leptin. Percent body fat and HDL-C account for a variance in leptin levels of 76% in young female college students.
Conclusions: We concluded that in order to properly adjust the level of leptin in female college students, a most effective strategy is to reduce percent body fat, WHR, BMI, LDL-C, TG, and CRP.
|
|
|
KEYWORD
|
|
|
obesity-linked factors, inflammatory factors, leptin hormone, college female students
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|